Dr. Christine E. Brown is the Heritage Provider Network Professor in Immunotherapy, Professor in the departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology and the Deputy Director of the T Cell Therapeutics Research Laboratories (TCTRL). She earned her Ph.D. from the University of California, Berkeley, and postdoctoral fellowship at Pennsylvania State University. Dr. Brown joined City of Hope in 2001 to help build its CAR T cell program. She is internationally recognized for her pioneering work in CAR T cell therapy, particularly its application to brain tumors.

Her research led to the first reported complete clinical response mediated by CAR T cells in a patient with glioblastoma, a landmark achievement in the field of solid tumor immunotherapy. Dr. Brown has spearheaded the development of glioblastoma-targeted CAR T cells, advancements in T cell manufacturing, and novel delivery approaches. These efforts have culminated in the initiation of multiple first-in-human clinical trials, including CAR T cells targeting IL13Rα2, HER2, and chlorotoxin (CLTX). As Deputy Director of TCTRL, Dr. Brown provides scientific oversight for TCTRL translational programs, which are dedicated to accelerating the clinical testing of CAR T cell therapy. Over the past decade, she has led and built multi-disciplinary teams for CAR T cell GMP manufacturing, quality control release, patient correlative studies and regulatory protocol management.